Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120005
DOI	10.4251/wjgo.120005
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Integration of cytogenetic aberrations and in-silico pathway enrichment identifies novel candidate genes in esophageal squamous cell carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Jagjeet Kaur, Vasudha Sambyal, Kamlesh Guleria, Manjit Singh Uppal and Meena Sudan
Funding Agency and Grant Number
Corresponding Author	Jagjeet Kaur, PhD, Department of Human Genetics, Guru Nanak DEv University, Grand Trunk Road, Amritsar 143005, Punjab, India. jagjeet30.jb@gmail.com
Key Words	Esophageal cancer; Cytogenetic analysis; Chromosomal aberrations; Genetic instability; Oncogenes; Pathway analysis
Core Tip	This study highlights the role of chromosomal instability in esophageal cancer. By analyzing 135 patients, researchers found significantly higher chromosomal aberrations compared to controls. In-silico analysis identified key genes like STAT3 and TP53, plus 12 genes enriched in the RNA polymerase II pathway. These findings reveal new genetic markers, offering deeper insights into esophageal cancer development and progression.
Citation	Kaur J, Sambyal V, Guleria K, Uppal MS, Sudan M. Integration of cytogenetic aberrations and in-silico pathway enrichment identifies novel candidate genes in esophageal squamous cell carcinoma. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.120005
PDF	120005-in-press.pdf

Received	2026-02-14 02:52
Peer-Review Started	2026-02-14 03:00
First Decision by Editorial Office Director	2026-02-26 07:17
Return for Revision	2026-02-26 07:17
Revised	2026-03-10 17:24
Publication Fee Transferred	2026-03-27 14:35
Second Decision by Editor	2026-06-04 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 07:54
Articles in Press	2026-06-04 07:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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