Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120019
Country	Czech Republic

Category	Oncology
Manuscript Type	Evidence Review
Article Title	Bridging the intraductal papillary mucinous neoplasm risk stratification gap: A critical review of current and emerging biomarkers
Manuscript Source	Unsolicited Manuscript
All Author List	Peter Mačinga, Jiří Zahradník, Tomáš Hucl and Radoslav Janoštiak
Funding Agency and Grant Number	Funding Agency Grant Number Czech Health Research Council NU23J-06-00043 Charles University PRIMUS Program PRIMUS/22/MED/007 European Union-Next Generation EU, Programme EXCELES LX22NPO5102
Corresponding Author	Radoslav Janoštiak, Associate Professor, PhD, Professor, BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, Vestec 25250, Czech Republic. radoslav.janostiak@lf1.cuni.cz
Key Words	Pancreatic cancer; Intraductal papillary mucinous neoplasms; Biomarker; Risk stratification; Cyst fluid; Liquid biopsy
Core Tip	Current guidelines for intraductal papillary mucinous neoplasm management inadequately distinguish indolent lesions from high grade dysplasia, resulting in both overtreatment and missed cancer. This evidence review critically examines established and emerging circulating and cyst fluid biomarkers, including molecular, inflammatory, and glycoprotein markers. We emphasize diagnostic performance, methodological limitations, and translational barriers. We highlight the impact of pooled histological endpoints, small surgical cohorts, assay heterogeneity, and lack of multicenter validation on the accuracy of the current studies. Finally, we outline the requirements needed to clinically integrate these biomarkers into intraductal papillary mucinous neoplasm risk stratification.
Citation	Mačinga P, Zahradník J, Hucl T, Janoštiak R. Bridging the intraductal papillary mucinous neoplasm risk stratification gap: A critical review of current and emerging biomarkers. World J Gastrointest Oncol 2026; In press

Received	2026-02-13 02:50
Peer-Review Started	2026-02-13 02:54
First Decision by Editorial Office Director	2026-03-04 09:11
Return for Revision	2026-03-06 09:56
Revised	2026-03-31 18:51
Publication Fee Transferred
Second Decision by Editor	2026-04-20 02:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-20 06:51
Articles in Press	2026-04-20 06:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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