Publication Name	World Journal of Gastroenterology
Manuscript ID	120035
DOI	10.3748/wjg.120035
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Dual effects of a high-protein diet on metabolic dysfunction-associated steatotic liver disease: Basic research on precision clinical interventions
Manuscript Source	Invited Manuscript
All Author List	Ya-Rong Ma, Wen-Long Miao, Na Li, Gui-Zhen Zhang and Zhi-Gang Ren
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 82470654 the Natural Science Foundation Key Project of Henan Province 232300421124 the Henan Zhongyuan Medical Science and Technology Innovation and Development Foundation ZYYC202301ZD the Postdoctoral Fellowship Program of the China Postdoctoral Science Foundation GZC20232430
Corresponding Author	Zhi-Gang Ren, MD, PhD, Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, No. 46 Jianshe East Road, Zhengzhou 450052, Henan Province, China. fccrenzg@zzu.edu.cn
Key Words	High-protein diet; Metabolic dysfunction-associated steatotic liver disease; Precision nutrition; Intestinal microbiota; Plant-based protein
Core Tip	A high-protein diet has dual effects on metabolic dysfunction-associated steatotic liver disease (MASLD), with protein source, intake level, and host metabolic phenotype serving as key regulators. Although previous studies have established a framework involving the gut–liver axis and amino acid pathways, gaps persist in causal mechanisms, intake thresholds, and clinical translation of multiomic findings. Future work should prioritize validating plant-based protein bioactivities, developing personalized algorithms that integrate host–microbiota interactions, and conducting long-term randomized controlled trials for precise MASLD dietary guidance.
Citation	Ma YR, Miao WL, Li N, Zhang GZ, Ren ZG. Dual effects of a high-protein diet on metabolic dysfunction-associated steatotic liver disease: Basic research on precision clinical interventions. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120035

Received	2026-02-13 03:04
Peer-Review Started	2026-02-13 03:04
First Decision by Editorial Office Director	2026-03-02 09:06
Return for Revision	2026-03-02 09:06
Revised	2026-04-15 15:28
Publication Fee Transferred
Second Decision by Editor	2026-06-01 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-02 08:13
Articles in Press	2026-06-02 08:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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