Publication Name	World Journal of Nephrology
Manuscript ID	120037
DOI	10.5527/wjn.120037
Country	Egypt

Category	Clinical Neurology
Manuscript Type	Randomized Controlled Trial
Article Title	Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label
Manuscript Source	Unsolicited Manuscript
All Author List	Ashraf Hassan Abd El Mobdy, Hayam Ahmed Hebah, Mohammed Ali Ezzat, Basant Abdelkarim Eid Mohamed and Fatma Abdelrahman Ahmed
Funding Agency and Grant Number
Corresponding Author	Ashraf Hassan Abd El Mobdy, Internal Medicine and Nephrology, Faculty of Medicine, Ain shams University, Cairo, Egypt., Ahmed Fakhry Street, Nasr City, Cairo, Egypt, Cairo 31511, Al Qāhirah, Egypt. ashrafnephro@med.asu.edu.eg
Key Words	Pentoxifylline; Inflammatory marker; Non-diabetic; Chronic kidney disease; Tumour necrosis factor-alpha
Core Tip	This randomized controlled study evaluated the effect of pentoxifylline (PTX) on inflammation and disease progression in non-diabetic chronic kidney disease (CKD) stages 3-4. Adding PTX to standard therapy significantly reduced C-reactive protein and proteinuria compared with standard treatment alone. Changes in tumour necrosis factor-alpha were inversely correlated with estimated glomerular filtration rate and urinary protein-to-creatinine ratio, highlighting a link between inflammation and renal function decline. PTX may offer additional anti-inflammatory and renoprotective benefits in non-diabetic CKD.
Citation	Abd El Mobdy AH, Hebah HA, Ezzat MA, Eid Mohamed BA, Ahmed FA. Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.120037
PDF	120037-in-press.pdf

Received	2026-02-13 02:35
Peer-Review Started	2026-02-13 02:35
First Decision by Editorial Office Director	2026-03-03 09:30
Return for Revision	2026-03-03 09:30
Revised	2026-04-04 13:59
Publication Fee Transferred	2026-05-01 11:34
Second Decision by Editor	2026-07-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 08:09
Articles in Press	2026-07-02 08:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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