Publication Name	World Journal of Virology
Manuscript ID	120048
Country	Morocco

Category	Immunology
Manuscript Type	Minireviews
Article Title	Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview
Manuscript Source	Invited Manuscript
All Author List	Abdellatif Bouayad
Funding Agency and Grant Number
Corresponding Author	Abdellatif Bouayad, Associate Professor, MD, Department of Immunology, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Hay al Hikma, Oujda 4867, Oriental, Morocco. abdellatifbouayad@hotmail.fr
Key Words	Soluble human leukocyte antigen-G; Virus-associated cancers; Immune escape; Diagnostic biomarker; Prognostic biomarker; Immune evasion
Core Tip	Increased soluble human leukocyte antigen-G (sHLA-G) levels are consistently associated with poor prognosis in hepatitis C virus/hepatitis B virus -related hepatocellular carcinoma and human papillomavirus-driven cervical cancer, underscoring its potential as a diagnostic and prognostic biomarker. High-risk human papillomavirus oncoproteins (E6 and E7) and hepatitis C virus proteins (core protein and nonstructural protein 3) may contribute to increased sHLA-G levels through cytokine-mediated immunosuppressive signalling pathways. The mechanisms by which sHLA-G-immunoglobulin-like transcript 2/immunoglobulin-like transcript 4 interactions modulate immune suppression in these virus-driven cancers remain incompletely understood. sHLA-G isoforms are primarily detected in plasma and other biological fluids using sandwich enzyme-linked immunosorbent assays, providing a reliable method for both clinical and research applications.
Citation	Bouayad A. Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview. World J Virol 2026; In press

Received	2026-02-13 01:52
Peer-Review Started	2026-02-13 01:52
First Decision by Editorial Office Director	2026-02-26 07:29
Return for Revision	2026-02-26 07:29
Revised	2026-03-08 11:25
Publication Fee Transferred
Second Decision by Editor	2026-04-14 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-14 10:05
Articles in Press	2026-04-14 10:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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