Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120066
Country	Singapore

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	James Guoxian Huang, Carina Jing-Xuan Tay, Marion Margaret Aw, Yung-Seng Lee and Delicia Shu-Qin Ooi
Funding Agency and Grant Number	Funding Agency Grant Number the Exxon-Mobil National University Singapore Research Fellowship for Clinicians
Corresponding Author	James Guoxian Huang, Assistant Professor, Department of Paediatrics, Khoo Teck Puat - National University Children’s Medical Institute, National University Health System, 1E Kent Ridge Road, National University Health System Tower Block, Level 12, Singapore 119228, Singapore. paehgj@nus.edu.sg
Key Words	Inflammatory bowel disease; Pediatrics; Metagenomic; Gut microbiome; Microbial shift; Functional shift
Core Tip	Using a longitudinal paired design, this paediatric inflammatory bowel disease metagenomic study shows that transition from active disease to remission is marked by a distinct gut microbiome with functional relevance. Remission was associated with enrichment of beneficial taxa (Anaerostipes hadrus, Bifidobacterium spp., Faecalibacterium prausnitzii, Lactobacillus gasseri) and metabolic pathways supporting short-chain fatty acid production, epithelial barrier repair, and immune modulation, whereas flare was dominated by Klebsiella pneumoniae. These findings highlight microbiome-derived functional pathways as promising targets for non-invasive biomarkers and microbiome-based therapeutic strategies to sustain remission in paediatric inflammatory bowel disease.
Citation	Huang JG, Tay CJX, Aw MM, Lee YS, Ooi DSQ. Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease. World J Clin Pediatr 2026; In press

Received	2026-02-14 02:34
Peer-Review Started	2026-02-14 02:35
First Decision by Editorial Office Director	2026-02-25 08:02
Return for Revision	2026-02-25 08:02
Revised	2026-03-10 07:06
Publication Fee Transferred
Second Decision by Editor	2026-05-14 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-14 06:52
Articles in Press	2026-05-14 06:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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