Publication Name	World Journal of Gastroenterology
Manuscript ID	120070
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Prospects for applying the results of studying the Sonic Hedgehog pathway to the diagnosis of metabolic dysfunction-associated steatohepatitis
Manuscript Source	Invited Manuscript
All Author List	Vladislav V Tsukanov, Alexander V Vasyutin, Edward V Kasparov and Julia L Tonkikh
Funding Agency and Grant Number
Corresponding Author	Vladislav V Tsukanov, Full Professor, MD, PhD, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, 3-G Partizan Zheleznyak Street, Krasnoyarsk 660022, Russia. gastro@impn.ru
Key Words	Sonic Hedgehog; Hedgehog signaling; Metabolic dysfunction-associated steatohepatitis; Liver fibrosis; Hepatocyte ballooning
Core Tip	The Sonic Hedgehog (SHH) signaling plays an important role in the development of animals by regulating organogenesis, tissue homeostasis, and regeneration. In a number of studies, it has been established that SHH dysregulation is associated with progression of metabolic dysfunction-associated steatohepatitis. In this regard, Han et al, who combined modern fundamental ideas with a high-class histological examination of the liver and established a strong correlation of SHH with steatosis, inflammation and liver fibrosis in metabolic dysfunction-associated steatohepatitis patients, certainly deserve approval and further development of their research.
Citation	Tsukanov VV, Vasyutin AV, Kasparov EV, Tonkikh JL. Letter to the Editor: Prospects for applying the results of studying the Sonic Hedgehog pathway to the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; In press

Received	2026-02-14 02:33
Peer-Review Started	2026-02-14 02:35
First Decision by Editorial Office Director	2026-03-27 12:42
Return for Revision	2026-03-27 12:42
Revised	2026-04-02 06:19
Publication Fee Transferred
Second Decision by Editor	2026-05-11 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-11 08:15
Articles in Press	2026-05-11 08:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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