Publication Name	World Journal of Psychiatry
Manuscript ID	120073
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Effect of sodium valproate on aripiprazole pharmacokinetics and initial dosage optimization in bipolar disorder
Manuscript Source	Unsolicited Manuscript
All Author List	Su-Mei He, Chang-Xiao Zhang, Ying-Wei Jin, Lei Jiang, Cun Zhang, Yi-Guo Jiang and Dong-Dong Wang
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science (Natural Science) Project of Higher Education Institutions in Jiangsu Province 25KJD310004 Suzhou Applied Basic Research Science and Technology Innovation Project SYWD2024258 Jiangsu Province Higher Education Informatization Research Project 2023JSETKT136 Xuzhou Medical University Research Project on Reform of Postgraduate Education and Teaching XYJGKT202506 Xuzhou Medical University Teaching Academic Research Project 2024ZDKT02-Y03
Corresponding Author	Dong-Dong Wang, Adjunct Professor, PhD, Principal Investigator, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy and School of Pharmacy, Xuzhou Medical University, No. 209 Tongshan Road, Xuzhou 221004, Jiangsu Province, China. 13852029591@163.com
Key Words	Drug–drug interactions; Initial dosage optimization; Aripiprazole; Bipolar disorder; Virtual clinical trial
Core Tip	This study aims to explore drug-drug interactions and initial dosage optimization of aripiprazole in patients with bipolar disorder (BD). Aripiprazole clearance rate increases 66.7% in patients with BD taking sodium valproate sustained-release tablet. The present study explores the drug-drug interactions and initial dosage optimization of aripiprazole in patients with BD based on virtual clinical trial for the first time. When sodium valproate sustained-release tablet is used in combination, the clearance of aripiprazole in patients with BD is accelerated, and the dosage of aripiprazole in patients with BD need to be increased.
Citation	He SM, Zhang CX, Jin YW, Jiang L, Zhang C, Jiang YG, Wang DD. Effect of sodium valproate on aripiprazole pharmacokinetics and initial dosage optimization in bipolar disorder. World J Psychiatry 2026; In press

Received	2026-02-14 03:13
Peer-Review Started	2026-02-14 03:13
First Decision by Editorial Office Director	2026-03-09 08:39
Return for Revision	2026-03-09 08:39
Revised	2026-03-21 02:38
Publication Fee Transferred	2026-03-24 04:43
Second Decision by Editor	2026-04-15 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-15 05:39
Articles in Press	2026-04-15 05:39
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ISSN	2220-3206 (online)
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