Publication Name	World Journal of Cardiology
Manuscript ID	120097
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Landiolol attenuates atrial remodeling in septic rats by upregulating calumenin
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Hui He, Lian-Kui Wu, Hao Liu, Ling-Yu Bai, Jian-Jun Du, Kui-Ying Ma, Yu Wang and Ming Zhao
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Inner Mongolia Autonomous Region of China No. 2023LHMS08082 Natural Science Foundation of Inner Mongolia Autonomous Region of China No. 2018MS08036 Natural Science Foundation of Inner Mongolia Autonomous Region of China No. 2021MS08069 Scientific Research in Higher Education Institutions of the Inner Mongolia Autonomous Region, China No. NJZY22456
Corresponding Author	Ming Zhao, Chief Physician, PhD, Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia Minzu University, No. 22 Holin He Street, Tongliao 028000, Inner Mongolia Autonomous Region, China. langzhe73@163.com
Key Words	Sepsis; Atrial fibrillation; Landiolol; Calumenin; Endoplasmic reticulum stress
Core Tip	This study first established a sepsis rat model and validated the modeling success by detecting elevated serum inflammatory cytokine levels using enzyme-linked immunosorbent assay. The model was treated with landiolol to compare the degree of inflammatory injury, myocardial fibrosis, and changes in atrial electrophysiology among the different groups. Immunofluorescence, immunohistochemistry, and Western blot analyses were performed to detect the expression of apoptosis-related proteins and endoplasmic reticulum stress-related proteins (glucose-regulated protein 78 and C/EBP homologous protein) and calumenin. The results indicated that landiolol may protect the myocardium by upregulating calumenin expression, thereby mitigating atrial electrical and structural remodeling in sepsis rats.
Citation	He ZH, Wu LK, Liu H, Bai LY, Du JJ, Ma KY, Wang Y, Zhao M. Landiolol attenuates atrial remodeling in septic rats by upregulating calumenin. World J Cardiol 2026; In press

Received	2026-02-24 05:38
Peer-Review Started	2026-02-24 05:38
First Decision by Editorial Office Director	2026-02-28 06:50
Return for Revision	2026-02-28 06:50
Revised	2026-03-13 07:10
Publication Fee Transferred	2026-03-16 08:17
Second Decision by Editor	2026-05-28 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-28 06:52
Articles in Press	2026-05-28 06:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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