Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	120122
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Nor-ursodeoxycholic acid in hepatobiliary diseases: A narrative review
Manuscript Source	Invited Manuscript
All Author List	Sayan Malakar, Neha Sood, Suprabhat Giri and Arghya Samanta
Funding Agency and Grant Number
Corresponding Author	Sayan Malakar, Assistant Professor, Department of Hepatology and Liver Transplantation, Punjab Institute of Liver and Biliary Sciences, 1210 Sector 77, Mohali 160059, Punjab, India. oneandonlydrsayan@gmail.com
Key Words	Nor-ursodeoxycholic acid; Norucholic acid; Primary sclerosing cholangitis; Cholehepatic shunt; Bicarbonate umbrella; Metabolic dysfunction-associated steatotic liver disease
Core Tip	Nor-ursodeoxycholic acid or norucholic acid is a short-chain shortened derivative of ursodeoxycholic acid. Pre-clinical animal studies have revealed conflicting results. Clinical data on primary cholestatic liver diseases and metabolic dysfunction-associated liver diseases are also limited. This narrative review comprehensively explores the mechanism of action and discusses the pharmacokinetics and pharmacodynamic differences with ursodeoxycholic acid. It also addresses the potential gap in the literature regarding the role of nor-ursodeoxycholic acid in metabolic dysfunction-associated liver diseases and primary sclerosing cholangitis based on primitive data.
Citation	Malakar S, Sood N, Giri S, Samanta A. Nor-ursodeoxycholic acid in hepatobiliary diseases: A narrative review. World J Gastrointest Pharmacol Ther 2026; In press

Received	2026-02-24 07:39
Peer-Review Started	2026-02-24 07:41
First Decision by Editorial Office Director	2026-03-26 10:18
Return for Revision	2026-03-26 10:18
Revised	2026-04-09 19:05
Publication Fee Transferred
Second Decision by Editor	2026-05-29 03:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-29 08:52
Articles in Press	2026-05-29 08:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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