Publication Name	World Journal of Clinical Cases
Manuscript ID	120126
Country	United States

Category	Medicine, General & Internal
Manuscript Type	Case Report
Article Title	Refractory rosuvastatin-associated necrotizing autoimmune myopathy: A case report and review of literature
Manuscript Source	Invited Manuscript
All Author List	Mrudula Thiriveedi, Hersh Patel and Punuru J Reddy
Funding Agency and Grant Number
Corresponding Author	Mrudula Thiriveedi, Chief Physician, MD, Department of Internal Medicine, Decatur Morgan Hospital, 1201 7th Street SE, Decatur, AL 35601, United States. drmrudula.giridhar@gmail.com
Key Words	Statin-associated necrotizing autoimmune myopathy; Anti-3-hydroxy-3-methylglutaryl–coenzyme A reductase antibodies; Rosuvastatin; Immune-mediated myopathy; Rhabdomyolysis; Case report
Core Tip	Statin-associated necrotizing autoimmune myopathy (NAM) is a rare immune-mediated myopathy defined by progressive weakness, marked creatine kinase elevation, and persistence of disease activity despite statin withdrawal, most often associated with anti-3-hydroxy-3-methylglutaryl–coenzyme A reductase antibodies. Many patients respond to corticosteroids and intravenous immunoglobulin (IVIG), but refractory disease can occur, particularly when diagnosis is delayed or when severe systemic complications develop. We report an elderly woman receiving long-term rosuvastatin who developed persistent rhabdomyolysis with dialysis-dependent renal failure and died despite high-dose corticosteroids, IVIG, and rituximab. This case underscores the need for early antibody testing and prompt escalation of therapy when statin-associated NAM is suspected, to prevent severe outcomes.
Citation	Thiriveedi M, Patel H, Reddy PJ. Refractory rosuvastatin-associated necrotizing autoimmune myopathy: A case report and literature review. World J Clin Cases 2026; In press

Received	2026-02-24 06:59
Peer-Review Started	2026-02-24 07:01
First Decision by Editorial Office Director	2026-03-03 09:23
Return for Revision	2026-03-03 09:23
Revised	2026-03-10 00:08
Publication Fee Transferred
Second Decision by Editor	2026-04-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-02 06:50
Articles in Press	2026-04-02 06:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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