Publication Name	World Journal of Clinical Cases
Manuscript ID	120145
Country	United Kingdom

Category	Surgery
Manuscript Type	Case Report
Article Title	Size-biology paradox in ampullary tumours - large-cell neuroendocrine carcinoma of the ampulla of Vater: A case report
Manuscript Source	Invited Manuscript
All Author List	Evangelia Florou, Abijith Velayutham, Yoh Zen, Justin Waters and Parthi Srinivasan
Funding Agency and Grant Number
Corresponding Author	Evangelia Florou, MD, Department of Hepato-Pancreato-Biliary Surgery, King’s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom. e.florou@nhs.net
Key Words	Ampullary carcinoma; Neuroendocrine carcinoma; Large-cell neuroendocrine carcinoma; Pancreaticoduodenectomy; Adjuvant chemotherapy; Ampulla of Vater; Case report
Core Tip	Large-cell neuroendocrine carcinoma (LCNEC) of the ampulla of Vater is a rare and aggressive malignancy that may present as a small lesion but requires oncologically intensive management. This striking discordance between tumour size, anatomical location, and biological behaviour underpins the size-biology paradox observed in ampullary LCNEC and highlights the importance of accurate histopathological classification and multidisciplinary oncological management.
Citation	Florou E, Velayutham A, Zen Y, Waters J, Srinivasan P. Size-biology paradox in ampullary tumours - large-cell neuroendocrine carcinoma of the ampulla of Vater: A case report. World J Clin Cases 2026; In press

Received	2026-02-26 02:50
Peer-Review Started	2026-02-26 02:52
First Decision by Editorial Office Director	2026-03-04 09:02
Return for Revision	2026-03-04 09:02
Revised	2026-03-08 17:16
Publication Fee Transferred
Second Decision by Editor	2026-03-19 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-19 07:46
Articles in Press	2026-03-19 07:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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