Publication Name	World Journal of Radiology
Manuscript ID	120146
Country	Saudi Arabia

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Minireviews
Article Title	Positron emission tomography tracers in medullary thyroid carcinoma: Current evidence and emerging targets
Manuscript Source	Invited Manuscript
All Author List	Fahad W Ahmed and Fauwad Ahmed
Funding Agency and Grant Number
Corresponding Author	Fahad W Ahmed, Consultant, FRCP, PhD, Department of Medical Oncology, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Madinah 42522, Saudi Arabia. fahadwali@yahoo.com
Key Words	Medullary thyroid carcinoma; Positron emission tomography; Fluorodihydroxyphenylalanine; Fluorodeoxyglucose; Somatostatin receptor; Calcitonin; Peptide receptor radionuclide therapy; Theranostics
Core Tip	Selecting the right positron emission tomography tracer in medullary thyroid carcinoma depends on tumour biology. This article synthesizes evidence from five databases indicating that fluorodihydroxyphenylalanine remains the most sensitive tracer for recurrent disease, whereas fluorodeoxyglucose better captures aggressive, dedifferentiated tumours. Somatostatin receptor imaging, though less sensitive overall, is indispensable for identifying candidates for peptide receptor radionuclide therapy. We propose an expert-informed, biology-guided algorithm linking biomarker kinetics to tracer choice and highlight cholecystokinin-2 receptor and fibroblast activation protein as promising emerging targets.
Citation	Ahmed FW, Ahmed F. Positron emission tomography tracers in medullary thyroid carcinoma: Current evidence and emerging targets. World J Radiol 2026; In press

Received	2026-02-24 07:23
Peer-Review Started	2026-02-24 07:25
First Decision by Editorial Office Director	2026-02-27 08:57
Return for Revision	2026-02-27 08:57
Revised	2026-03-05 14:34
Publication Fee Transferred
Second Decision by Editor	2026-04-01 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 04:21
Articles in Press	2026-04-01 04:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8470 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com