Publication Name	World Journal of Cardiology
Manuscript ID	120150
Country	Greece

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	When coronary spasm reflects systemic vascular disease: Prognostic insights from endothelial dysfunction
Manuscript Source	Invited Manuscript
All Author List	Nikolaos Ktenopoulos, Nikias Milaras, Anastasios Apostolos, Konstantinos Tsioufis, Konstantinos Toutouzas and Skevos Sideris
Funding Agency and Grant Number
Corresponding Author	Nikias Milaras, MD, Department of Cardiology, "Hippokration" General Hospital, Vasilisis Sofias 14, Athens 11527, Greece. nikiasmilaras@gmail.com
Key Words	Vasospastic angina; Endothelial dysfunction; Flow-mediated dilation; Coronary spasm; Prognosis; Risk stratification; Microvascular dysfunction
Core Tip	In patients with vasospastic angina, impaired brachial artery flow-mediated dilation independently predicts adverse cardiovascular events and outperforms conventional angiographic spasm markers. These data support the concept that coronary spasm reflects systemic endothelial pathology rather than isolated epicardial hyperreactivity, highlighting the potential role of endothelial function testing in clinical risk stratification.
Citation	Ktenopoulos N, Milaras N, Apostolos A, Tsioufis K, Toutouzas K, Sideris S. When coronary spasm reflects systemic vascular disease: Prognostic insights from endothelial dysfunction. World J Cardiol 2026; In press

Received	2026-02-24 07:32
Peer-Review Started	2026-02-24 07:32
First Decision by Editorial Office Director	2026-03-20 10:45
Return for Revision	2026-03-20 10:45
Revised	2026-04-10 16:51
Publication Fee Transferred
Second Decision by Editor	2026-05-13 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-13 07:43
Articles in Press	2026-05-13 07:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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