Publication Name	World Journal of Gastroenterology
Manuscript ID	120167
Country	China

Category	Anesthesiology
Manuscript Type	Prospective Study
Article Title	Postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: A prospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Guan-Yu Yang, Xiao-Fei Zhang, Xin Zhao, Huan Qu, Piao Zhou, Yan Wang, Shu-Min Tu, Zheng-Yuan Xia and Qin-Jun Chu
Funding Agency and Grant Number
Corresponding Author	Qin-Jun Chu, MD, PhD, Professor, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 16 Tongbai North Road, Zhongyuan District, Zhengzhou 450007, Henan Province, China. jimmynetchu@163.com
Key Words	Postoperative nausea and vomiting; Laparoscopic sleeve gastrectomy; Dexmedetomidine; Apfel score; Index of Nausea, Vomiting, and Retching
Core Tip	In this prospective cohort study of 1054 patients undergoing laparoscopic sleeve gastrectomy, postoperative nausea and vomiting (PONV) remained highly prevalent despite multimodal prophylaxis, affecting 76.3% of patients. Using the validated Index of Nausea, Vomiting, and Retching, we found that intraoperative dexmedetomidine was associated with lower odds of PONV, whereas Apfel scores of 3-4 were associated with a substantially increased risk even with guideline-based prevention. These findings suggest a potential benefit of dexmedetomidine in this setting, although randomized controlled trials are needed to confirm causality. More effective antiemetic strategies, including additional pharmacological and non-pharmacological approaches, may be warranted for patients at high risk of PONV after laparoscopic sleeve gastrectomy.
Citation	Yang GY, Zhang XF, Zhao X, Qu H, Zhou P, Wang Y, Tu SM, Xia ZY, Chu QJ. Postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: A prospective cohort study. World J Gastroenterol 2026; In press

Received	2026-02-24 03:51
Peer-Review Started	2026-02-24 03:52
First Decision by Editorial Office Director	2026-03-09 09:15
Return for Revision	2026-03-09 09:15
Revised	2026-03-30 13:22
Publication Fee Transferred	2026-03-31 13:02
Second Decision by Editor	2026-05-25 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-25 08:00
Articles in Press	2026-05-25 08:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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