Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120170
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Yuan Ren, Hong-Yan Zhang, Chen-Xi Xie, Geng-Ping Zhou, Peng-Yu Chen, Hao Yuan, Kai Zhang, Yang Xu, Yang-Yang Wang, Tai-Yang Chen, Qing-Shan Li and Hai-Bo Yu
Funding Agency and Grant Number	Funding Agency Grant Number Henan Young and Middle-aged Health Science and Technology Innovation Leading Talents Training Project YXKC2022002
Corresponding Author	Hai-Bo Yu, PhD, Hepatobiliary and Pancreatic Surgery, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Zhengzhou, 450003, China, Zhengzhou 450003, Henan, China. yhb2101661@zzu.edu.cn
Key Words	Cholangiocarcinoma; IQGAP1; MCM3; Nrf2; Apoptosis
Core Tip	This study reveals for the first time that IQGAP1 drives cholangiocarcinoma progression by recruiting ubiquitin-specific peptidase 28 to stabilize MCM3 protein, inhibiting its ubiquitination. This stabilization activates the Nrf2 pathway, alleviating oxidative stress and suppressing apoptosis, thereby promoting tumor cell survival and growth. Inhibition of MCM3 reverses these effects. The findings identify IQGAP1 as a key regulator of the MCM3/Nrf2 axis and a promising therapeutic target.
Citation	Ren ZY, Zhang HY, Xie CX, Zhou GP, Chen PY, Yuan H, Zhang K, Xu Y, Wang YY, Chen TY, Li QS, Yu HB. IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma. World J Gastrointest Oncol 2026; In press

Received	2026-02-24 03:49
Peer-Review Started	2026-02-24 03:50
First Decision by Editorial Office Director	2026-03-12 07:58
Return for Revision	2026-03-12 07:58
Revised	2026-04-06 09:16
Publication Fee Transferred	2026-04-08 15:54
Second Decision by Editor	2026-05-07 03:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 08:16
Articles in Press	2026-05-07 08:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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