Publication Name	World Journal of Orthopedics
Manuscript ID	120195
Country	India

Category	Biochemistry & Molecular Biology
Manuscript Type	Observational Study
Article Title	MiR 26a as a stage-dependent biomarker and therapeutic regulator of inflammation in knee osteoarthritis
Manuscript Source	Invited Manuscript
All Author List	Vijetha Gunamala, Rajeswary Hari, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	MicroRNA-26a2; MicroRNA-26a5; NF κB; MMP-13; Osteoarthritis
Core Tip	MiR 26a5, identified as a stage-specific biomarker for osteoarthritis of the knee (KOA), has its levels inversely correlated with the NF-κB, COX 2, MMP 13 and NOS2 expression. In contrast to lowly involved miR 26a2, miR 26a5 protects against inflammation-induced cartilage degradation. Its loss of function speeds up the disease process, highlighting its therapeutic potential and utility in measuring the level of KOA, despite small sample sizes and short-term studies.
Citation	Gunamala V, Hari R, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. MiR 26a as a stage-dependent biomarker and therapeutic regulator of inflammation in knee osteoarthritis. World J Orthop 2026; In press

Received	2026-02-24 07:12
Peer-Review Started	2026-02-24 07:13
First Decision by Editorial Office Director	2026-03-05 09:38
Return for Revision	2026-03-05 09:38
Revised	2026-03-08 13:18
Publication Fee Transferred
Second Decision by Editor	2026-05-26 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-26 07:58
Articles in Press	2026-05-26 07:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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