Publication Name	World Journal of Cardiology
Manuscript ID	120236
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Circulating microRNAs as biomarkers of cardiovascular disease: A systematic review
Manuscript Source	Unsolicited Manuscript
All Author List	Apurva Popat, Srinivasulu Yerukala Sathipati and Param P Sharma
Funding Agency and Grant Number
Corresponding Author	Apurva Popat, MD, Department of Cardiology, Marshfield Clinic, 1000 N Oak Ave, Marshfield, WI, 54449, Marshfield, WI 5449, United States. drapurvapopat@gmail.com
Key Words	Cardiovascular disease; MicroRNAs; Biomarkers; Extracellular biomarkers; Precision medicine
Core Tip	This systematic review summarizes current evidence on circulating microRNAs (miRNAs) as diagnostic and prognostic biomarkers across cardiovascular disease, including acute coronary syndromes, coronary artery disease, heart failure, stroke, cardiogenic shock, and hypertension. Several miRNAs showed promising disease-specific signals, including miR-133a, miR-328, miR-423-5p, miR-19a, and miR-21. However, clinical translation remains limited by heterogeneity in sampling methods, assay platforms, normalization strategies, and limited external validation. Standardized multicenter prospective studies are needed before circulating miRNAs can be incorporated into routine cardiovascular risk stratification.
Citation	Popat A, Sathipati SY, Sharma PP. Circulating microRNAs as biomarkers of cardiovascular disease: A systematic review. World J Cardiol 2026; In press

Received	2026-02-24 08:52
Peer-Review Started	2026-02-24 08:53
First Decision by Editorial Office Director	2026-04-04 02:26
Return for Revision	2026-04-04 02:26
Revised	2026-05-03 06:02
Publication Fee Transferred	2026-05-11 17:44
Second Decision by Editor	2026-06-03 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 01:08
Articles in Press	2026-06-04 01:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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