Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120240
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	E74-like E26 transformation-specific transcription factor 3 in gastric cancer: Functions, mechanisms, and clinical translation - unresolved issues
Manuscript Source	Invited Manuscript
All Author List	Yun-Jun Yan, Zhen Yang, Ruo-Yu Chao and Jun-Li Shi
Funding Agency and Grant Number
Corresponding Author	Yun-Jun Yan, PhD, /, Jinan Vocational College of Nursing, No. 3636 Gangxi Road, Licheng District, Jinan 250102, Shandong Province, China. yanyunjunou@163.com
Key Words	Gastric cancer; E74-like E26 transformation-specific transcription factor 3; Immune evasion; Tumor microenvironment; Prognostic biomarker; Targeted therapy
Core Tip	E74-like E26 transformation-specific transcription factor 3 (ELF3) exhibits context-dependent functions in gastric cancer. Present evidence supports its pro-tumorigenic role through the regulation of epithelial-mesenchymal transition and immune evasion, although functional validation remains required. Patients with high ELF3 expression present with a “cold” tumor phenotype that may limit the responsiveness to immunotherapy. Future research should focus on completing the chain of functional validation and systematically evaluating existing ELF3-targeting compounds in gastric cancer models, particularly in combination with immune checkpoint inhibitors.
Citation	Yan YJ, Yang Z, Chao RY, Shi JL. E74-like E26 transformation-specific transcription factor 3 in gastric cancer: Functions, mechanisms, and clinical translation - unresolved issues. World J Gastrointest Oncol 2026; In press

Received	2026-02-24 01:19
Peer-Review Started	2026-02-24 01:22
First Decision by Editorial Office Director	2026-03-06 08:36
Return for Revision	2026-03-06 08:36
Revised	2026-03-26 05:29
Publication Fee Transferred
Second Decision by Editor	2026-05-07 03:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 08:44
Articles in Press	2026-05-07 08:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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