Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120245
Country	China

Category	Oncology
Manuscript Type	Opinion Review
Article Title	C-reactive protein/albumin ratio in immunochemotherapy for advanced gastric cancer: Prognostic value, clinical challenges, and future directions
Manuscript Source	Invited Manuscript
All Author List	Yan-Song Hou, Ze-Yuan Yu and Xiao-Jun Yang
Funding Agency and Grant Number
Corresponding Author	Xiao-Jun Yang, Associate Professor, Chief Physician, MD, Department of Hepatobiliary Surgery, Gansu Provincial Hospital, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com
Key Words	Gastric cancer; C-reactive protein-to-albumin ratio; Immunochemotherapy; Prognosis; Inflammation; Nutrition
Core Tip	C-reactive protein/albumin ratio (CAR) has attracted attention because it is easy to obtain, highly reproducible in clinical practice, and biologically linked to systemic inflammation, malnutrition, cachexia, treatment tolerance, and immune competence. We argue that, in Immunochemotherapy for advanced gastric cancer, the greatest value of CAR is not as an independent determinant of treatment selection, but as a complementary host-state biomarker that should be interpreted alongside programmed death ligand 1, mismatch repair status, metastatic burden, and performance status. The field now needs prospective validation, dynamic monitoring of CAR, and clinical trials testing whether CAR-guided nutritional or anti-inflammatory interventions can improve clinically meaningful outcomes.
Citation	Hou YS, Yu ZY, Yang XJ. C-reactive protein/albumin ratio in immunochemotherapy for advanced gastric cancer: Prognostic value, clinical challenges, and future directions. World J Gastrointest Oncol 2026; In press

Received	2026-02-24 01:13
Peer-Review Started	2026-02-24 01:14
First Decision by Editorial Office Director	2026-02-27 08:47
Return for Revision	2026-02-27 08:47
Revised	2026-03-09 12:13
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 05:44
Articles in Press	2026-05-06 05:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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