Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	120256
DOI	10.4292/wjgpt.120256
Country	Pakistan

Category	Anesthesiology
Manuscript Type	Meta-Analysis
Article Title	Hemodynamic safety of remimazolam vs propofol in elderly patients
Manuscript Source	Invited Manuscript
All Author List	Nawal Tahir, Adil Khan, Sidra Faryal, Muhammad Faizan, Ayesha Irshad, Umer Iqbal, Muaaz Wasay, Syed A Arsal, Aashish kumar, Inibehe I Okon and Shafin Bin Amin
Funding Agency and Grant Number
Corresponding Author	Umer Iqbal, Academic Fellow, Department of Anesthesiology, Pain Management and Surgical Intensive Care, The Indus Hospital, Korangi Campus, Plot C-76, Sector 31/5, Opposite، Crossing, Darussalam Society Sector 39 Korangi, Karachi 75190, Sindh, Pakistan. umer.iqbal@tih.org.pk
Key Words	Remimazolam; Propofol; Endoscopy; Colonoscopy; Procedural sedation
Core Tip	This meta-analysis of 10 randomized controlled trials involving 1994 elderly patients establishes the superior hemodynamic safety of remimazolam over propofol during gastrointestinal endoscopy. Remimazolam reduced the risk of hypotension by more than half compared to propofol, while significantly lowering incidences of bradycardia, respiratory depression, and injection pain. Crucially, these safety advantages were achieved without compromising recovery times or increasing post-operative nausea. These quantitative findings demonstrate that remimazolam serves as a safer, highly stable sedative alternative for mitigating cardiorespiratory risks in vulnerable older populations.
Citation	Tahir N, Khan A, Faryal S, Faizan M, Irshad A, Iqbal U, Wasay M, Arsal SA, Kumar A, Okon II, Amin SB. Hemodynamic safety of remimazolam vs propofol in elderly patients. World J Gastrointest Pharmacol Ther 2026; In press DOI: https://doi.org/10.4292/wjgpt.120256
PDF	120256-in-press.pdf

Received	2026-02-24 06:29
Peer-Review Started	2026-02-24 06:32
First Decision by Editorial Office Director	2026-05-18 06:30
Return for Revision	2026-05-18 06:30
Revised	2026-05-31 05:39
Publication Fee Transferred
Second Decision by Editor	2026-06-18 02:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-18 06:42
Articles in Press	2026-06-18 06:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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