Publication Name	World Journal of Biological Chemistry
Manuscript ID	120297
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Mohammed S Abdulrahman, Omnia Aboelmagd, Ying Zhang, Samy Zaky and Dina Johar
Funding Agency and Grant Number
Corresponding Author	Dina Johar, PhD, Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Asma Fahme Street, Cairo 11757, Egypt. dinajohar@gu.edu.eg
Key Words	Hepatitis B virus; Precore/core mutations; Hepatocellular carcinoma; Reactivation; Lamivudine; Entecavir; Tenofovir alafenamide; Tenofovir disoproxil fumarate
Core Tip	Current antiviral treatments can slow down hepatitis B virus (HBV) replication and help improve liver damage. However, they rarely fully clear chronic HBV infections. There is an urgent need for new drugs and better strategies to combat the virus. The hypothesis that seroreactive viral infection is caused by mutation/s in the precore/core is invaluable to elucidating the mechanisms of HBV reactivation. This review re-analyzes clinically significant HBV precore/core mutations affecting pregenomic RNA initiation and synthesis, and their regulation of viral and cellular gene expressions. Further, it analyzes the effects of antivirals lamivudine, entecavir, tenofovir alafenamide, and immune-based strategies on viral reactivation after treatment.
Citation	Abdulrahman MS, Aboelmagd O, Zhang Y, Zaky S, Johar D. Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma. World J Biol Chem 2026; In press

Received	2026-02-25 03:19
Peer-Review Started	2026-02-25 03:19
First Decision by Editorial Office Director	2026-03-13 09:20
Return for Revision	2026-03-13 09:20
Revised	2026-04-20 00:05
Publication Fee Transferred
Second Decision by Editor	2026-05-26 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-26 08:19
Articles in Press	2026-05-26 08:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8454 (online)
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