Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120308
DOI	10.4251/wjgo.120308
Country	China

Category	Cell Biology
Manuscript Type	Opinion Review
Article Title	Metastasis-associated in colon cancer 1 in pancreatic cancer: Emerging evidence, unresolved questions, and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Hong-Fei Tan, Xue-Yuan Hu, Xia Yao, Rui Zhang, Jing-Feng Tang and Ce-Fan Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32270768, 82273970 Innovation Group Project of Hubei Province 2023AFA026 Key Cultivation Project of Hubei Province for Science and Technology 2024DJA037 National Natural Science Foundation of Hubei 2025AFA086
Corresponding Author	Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Key Words	Pancreatic cancer; Metastasis-associated in colon cancer 1; P53; Notch; Non-coding RNA
Core Tip	Current evidence shows that metastasis-associated in colon cancer 1 is not just a simple prognostic marker of pancreatic ductal adenocarcinoma. It is associated with tumor invasion, metastasis, chemotherapy resistance and multiple signaling pathways, and is regulated by upstream non-coding RNAs. However, its key functions, the mechanistic hierarchy and the context dependence are still unclear. This review summarizes the existing evidence, unresolved questions and future research directions, aiming to provide a reference for further elucidating the core regulatory mechanisms of metastasis-associated in colon cancer 1 in pancreatic ductal adenocarcinoma.
Citation	Tan HF, Hu XY, Yao X, Zhang R, Tang JF, Zhou CF. Metastasis-associated in colon cancer 1 in pancreatic cancer: Emerging evidence, unresolved questions, and future perspectives. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.120308
PDF	120308-in-press.pdf

Received	2026-02-24 01:02
Peer-Review Started	2026-02-24 01:04
First Decision by Editorial Office Director	2026-02-27 08:47
Return for Revision	2026-02-27 08:47
Revised	2026-04-28 12:28
Publication Fee Transferred
Second Decision by Editor	2026-06-15 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 06:29
Articles in Press	2026-06-15 06:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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