Publication Name	World Journal of Nephrology
Manuscript ID	120318
Country	Egypt

Category	Urology & Nephrology
Manuscript Type	Observational Study
Article Title	Role of fibroblast growth factor-23 in renal disease activity and bone density involvement in patients with lupus nephritis
Manuscript Source	Invited Manuscript
All Author List	Nashwa M Azoz, Ammar A Ammar, Howaida A Nafady, Rabea A Gadelkareem, Essam M Abdel Aziz and Randa A Elzohne
Funding Agency and Grant Number
Corresponding Author	Rabea A Gadelkareem, Assistant Professor, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71515, Egypt. rabeagad@aun.edu.eg
Key Words	Bone mineral density; Chronic kidney disease; Fibroblast growth factor-23; Lupus nephritis; Renal disease activity; Systemic lupus erythematosus
Core Tip	Fibroblast growth factor-23 (FGF-23) regulates mineral metabolism and may reflect both renal activity and skeletal involvement. The present study demonstrated that serum FGF-23 levels were significantly associated with renal disease activity and bone mineral metabolism (BMD) in patients with lupus nephritis. Elevated FGF-23 levels were correlated with impaired renal function and reduced BMD. Therefore, FGF-23 may be a valuable biomarker of renal disease activity and the risk of bone loss. Routine assessment of serum FGF-23 in patients with lupus nephritis may aid in risk stratification and disease monitoring. Additionally, those patients should undergo regular evaluation of BMD and mineral metabolism parameters.
Citation	Azoz NM, Ammar AA, Nafady HA, Gadelkareem RA, Abdel Aziz EM, Elzohne RA. Role of fibroblast growth factor-23 in renal disease activity and bone density involvement in patients with lupus nephritis. World J Nephrol 2026; In press

Received	2026-02-24 05:53
Peer-Review Started	2026-02-24 05:54
First Decision by Editorial Office Director	2026-03-06 09:18
Return for Revision	2026-03-06 09:18
Revised	2026-03-17 15:33
Publication Fee Transferred
Second Decision by Editor	2026-05-13 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-13 08:47
Articles in Press	2026-05-13 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com