Publication Name	World Journal of Gastroenterology
Manuscript ID	120338
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Helicobacter pylori eradication restores aspirin responsiveness - a thromboinflammatory interpretation
Manuscript Source	Invited Manuscript
All Author List	Jian-Jiang Song, Ning Li, Yong-Wei Yu and Shuai Liu
Funding Agency and Grant Number
Corresponding Author	Yong-Wei Yu, Academic Fellow, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Key Words	Helicobacter pylori; Aspirin resistance; Thromboinflammation; Platelet reactivity; Antiplatelet pharmacodynamics
Core Tip	Helicobacter pylori infection may influence cardiovascular outcomes beyond peptic ulcer disease, particularly in chronic aspirin users. Persistent infection can sustain a thromboinflammatory state that increases platelet turnover and reactivity, thereby weakening effective cyclooxygenase-1 inhibition and producing functional aspirin resistance. We propose that the apparent cardiovascular benefit after eradication may reflect pharmacologic resensitization rather than short-term vascular remodeling. This hypothesis-generating perspective links infection biology with antiplatelet pharmacodynamics and may help explain inter-individual variability in aspirin efficacy.
Citation	Song JJ, Li N, Yu YW, Liu S. Letter to the Editor: Helicobacter pylori eradication restores aspirin responsiveness - a thromboinflammatory interpretation. World J Gastroenterol 2026; In press

Received	2026-02-24 00:56
Peer-Review Started	2026-02-24 00:56
First Decision by Editorial Office Director	2026-03-27 12:51
Return for Revision	2026-03-27 12:51
Revised	2026-04-15 07:34
Publication Fee Transferred
Second Decision by Editor	2026-05-26 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-26 08:19
Articles in Press	2026-05-26 08:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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