Publication Name	World Journal of Psychiatry
Manuscript ID	120342
DOI	10.5498/wjp.120342
Country	China

Category	Psychology, Multidisciplinary
Manuscript Type	Editorial
Article Title	Alcohol dehydrogenase 4 in hepatocellular carcinoma: A novel biomarker that links tumor behavior to mental health
Manuscript Source	Invited Manuscript
All Author List	Shu-Qi Ren, Jia-Wei Chen and Chuang Cai
Funding Agency and Grant Number
Corresponding Author	Chuang Cai, PhD, Cancer Research Institute of Zhongshan City, Zhongshan City People’s Hospital, No. 2 Sunwen East Road, Zhongshan 528445, Guangdong Province, China. caich6@foxmail.com
Key Words	Alcohol dehydrogenase 4; Hepatocellular carcinoma; Tumor invasion; Survival prognosis; Mental health; Biomarker
Core Tip	Alcohol dehydrogenase 4 is markedly downregulated in hepatocellular carcinoma (HCC) tissues, and its expression level is closely correlated with tumor size, histological differentiation and microvascular invasion. It serves as an independent prognostic factor for HCC patients and is negatively associated with postoperative anxiety and depression. Alcohol dehydrogenase 4 may act as a novel biomarker for the integrated assessment of tumor biological behavior and patients’ psychological status in HCC, offering a new direction for the biopsychosocial comprehensive management of the disease.
Citation	Ren SQ, Chen JW, Cai C. Alcohol dehydrogenase 4 in hepatocellular carcinoma: A novel biomarker that links tumor behavior to mental health. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.120342
PDF	120342-in-press.pdf

Received	2026-02-24 00:55
Peer-Review Started	2026-02-24 00:56
First Decision by Editorial Office Director	2026-04-22 10:53
Return for Revision	2026-04-22 10:53
Revised	2026-05-22 19:27
Publication Fee Transferred
Second Decision by Editor	2026-06-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-11 07:15
Articles in Press	2026-06-11 07:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com