Publication Name	World Journal of Orthopedics
Manuscript ID	120345
Country	China

Category	Orthopedics
Manuscript Type	Opinion Review
Article Title	Neuroinflammatory regulation of fracture healing after traumatic brain injury: Clinical evidence and emerging mechanistic insights
Manuscript Source	Invited Manuscript
All Author List	Xi Chen, Shou-Xiang Kuang, Feng-Ge Zhou and Cheng-Gui Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82202701 Natural Science Foundation of Shandong Province, China ZR2022QH184 Taishan Scholars Program
Corresponding Author	Cheng-Gui Zhang, MD, PhD, Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 Jingshi Road, Jinan 250000, Shandong Province, China. chenggui1214@pku.edu.cn
Key Words	Traumatic brain injury; Fracture healing; Neuroendocrine regulation; Neuroinflammation; Sympathetic activation; Brain-bone crosstalk
Core Tip	Accelerated fracture healing associated with traumatic brain injury represents a distinct biological phenomenon that cannot be explained by single factor mechanisms. This paper proposes that an integrated regulatory network involving the nervous, immune, and endocrine systems underlies this process. By synthesizing clinical observations and experimental evidence, it highlights a system level framework and provides insight into the potential mechanisms of neuroendocrine and immune interactions in fracture repair.
Citation	Chen X, Kuang SX, Zhou FG, Zhang CG. Neuroinflammatory regulation of fracture healing after traumatic brain injury: Clinical evidence and emerging mechanistic insights. World J Orthop 2026; In press

Received	2026-02-24 00:55
Peer-Review Started	2026-02-24 00:56
First Decision by Editorial Office Director	2026-03-09 09:05
Return for Revision	2026-03-09 09:05
Revised	2026-04-18 13:53
Publication Fee Transferred
Second Decision by Editor	2026-05-22 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-22 08:22
Articles in Press	2026-05-22 08:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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