Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	120360
Country	China

Category	Transplantation
Manuscript Type	Basic Study
Article Title	Sutureless portal vein reconstruction in porcine orthotopic liver transplantation using microvascular coupler: Randomized study with artificial intelligence-assisted histopathology
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Jie Li, Jian Yang, Yan Xie, Jia-Ming Shang, Jiang Li, Chi-Yi Chen, Li-Na Liu, Zhong-Ying Zhang, Bing-Hui Pan and Wen-Tao Jiang
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Scientific Research Plan of Tianjin Municipal Education Commission No. 2024ZXZD010 Project of Tianjin Science and Technology Bureau Applied Basic Research No. 23JCYBJC01800 Beijing Hepatobiliary Sympathy Foundation Special Fund No. iGandan-1082025-RGG009
Corresponding Author	Wen-Tao Jiang, Chief Physician, Dean, Full Professor, Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, No. 2 Baoshan West Road, Xiqing District, Tianjin 300380, China. jiangwentao@nankai.edu.cn
Key Words	Microvascular anastomotic coupler; Sutureless anastomosis; Portal vein reconstruction; Porcine model; Liver transplantation; Artificial intelligence-assisted histopathology
Core Tip	This randomized porcine orthotopic liver transplantation study evaluates a microvascular anastomotic coupler for sutureless portal vein reconstruction. Compared with hand-sewn anastomosis, the coupler shortened anastomosis time by about 12 minutes while maintaining 12-week patency and portal hemodynamics. Quantitative, artificial intelligence-assisted (human-verified) histopathology demonstrated fewer inflammatory cells and smaller necrotic areas around the anastomosis, supporting a favorable local tissue response. These findings indicate that a simple, standardized coupler can reduce warm ischemia and technical variability without sacrificing vascular integrity, offering a practical pathway to streamline portal reconstruction in liver transplantation.
Citation	Li JJ, Yang J, Xie Y, Shang JM, Li J, Chen CY, Liu LN, Zhang ZY, Pan BH, Jiang WT. Sutureless portal vein reconstruction in porcine orthotopic liver transplantation using microvascular coupler: Randomized study with artificial intelligence-assisted histopathology. World J Gastrointest Surg 2026; In press

Received	2026-02-25 02:52
Peer-Review Started	2026-02-25 02:52
First Decision by Editorial Office Director	2026-03-20 09:48
Return for Revision	2026-03-20 09:48
Revised	2026-03-22 18:06
Publication Fee Transferred	2026-03-23 10:24
Second Decision by Editor	2026-05-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-25 06:41
Articles in Press	2026-05-25 06:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com