Publication Name	World Journal of Psychiatry
Manuscript ID	120370
DOI	10.5498/wjp.120370
Country	China

Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Neurobiological mechanisms and clinical implications of scene perception impairment in schizophrenia
Manuscript Source	Unsolicited Manuscript
All Author List	Zheng Fan, Ke-Ying Lv, Jing Zhang, Tian-Tian Wang, Xiao-Hong Liu, Wen-Liang Wang, Zhen-He Zhou and Hong-Liang Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Wuxi Taihu Talent Project WXTTP 2021
Corresponding Author	Zhen-He Zhou, Chief Physician, MD, PhD, Professor, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Wuxi 214151, Jiangsu Province, China. zhouzh@jiangnan.edu.cn
Key Words	Schizophrenia; Scene perception; Electrophysiology; Structural magnetic resonance imaging; Effective connectivity; Predictive coding
Core Tip	Scene perception impairment in schizophrenia is best understood as a multilevel disturbance that begins with early sensory prediction deficits and unfolds through visual-stream dysfunction, network dysconnectivity, and clinically relevant failures in social-scene interpretation. This review incorporates structural magnetic resonance imaging findings, expands the analysis of effective connectivity and feedforward-feedback abnormalities, links molecular evidence across gene, cell, circuit, and computational levels, and sharpens the discussion of translational implications. Taken together, the literature suggests that scene perception may offer a practical bridge between basic visual neuroscience and real-world functional outcomes.
Citation	Fan Z, Lv KY, Zhang J, Wang TT, Liu XH, Wang WL, Zhou ZH, Zhou HL. Neurobiological mechanisms and clinical implications of scene perception impairment in schizophrenia. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.120370
PDF	120370-in-press.pdf

Received	2026-02-26 01:30
Peer-Review Started	2026-02-26 01:31
First Decision by Editorial Office Director	2026-04-10 06:10
Return for Revision	2026-04-10 06:10
Revised	2026-04-27 13:08
Publication Fee Transferred	2026-05-01 13:16
Second Decision by Editor	2026-06-15 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 05:48
Articles in Press	2026-06-15 05:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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