Publication Name	World Journal of Methodology
Manuscript ID	120387
DOI	10.5662/wjm.120387
Country	United States

Category	Surgery
Manuscript Type	Systematic Reviews
Article Title	Impact of massive transfusion protocols on survival and complications in trauma: Umbrella review of systematic reviews and meta-analyses
Manuscript Source	Invited Manuscript
All Author List	Marcelo Augusto Fontenelle Ribeiro Junior, Rafael Dib Possiedi, Sariya Khan, Leticia Stefani Pacheco, Ridha Umar, Syed Fouzaan Albeez, Husna Irfan Thalib, Karine Matos de Albuquerque and Marcos Arcoverde Fortes Filho
Funding Agency and Grant Number
Corresponding Author	Marcelo Augusto Fontenelle Ribeiro Junior, FACS, Full Professor, MD, PhD, Professor, Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland, Rm. P1Go4G. 22 South Greene Street, Baltimore, MD 21201, United States. mfribeiro@som.umaryland.edu
Key Words	Massive transfusion; Trauma hemorrhage; Damage control resuscitation; Whole blood; Balanced blood component ratios; Survival; Transfusion-related complications
Core Tip	Severe traumatic hemorrhage remains a leading cause of preventable death. This umbrella review synthesizes systematic evidence on massive transfusion protocols, component ratios, and whole blood in trauma. Protocol implementation and higher component ratios were associated with reductions in selected early mortality endpoints, but overall evidence credibility was predominantly weak or suggestive, and no comparison reached convincing strength. Whole blood demonstrated reduced 24-hour mortality without consistent improvement in other clinical outcomes, indicating that clinical use should be guided by patient context, timing, and system-level factors.
Citation	Ribeiro Junior MAF, Dib Possiedi R, Khan S, Stefani Pacheco L, Umar R, Fouzaan Albeez S, Thalib HI, Matos de Albuquerque K, Arcoverde Fortes Filho M. Impact of massive transfusion protocols on survival and complications in trauma: Umbrella review of systematic reviews and meta-analyses. World J Methodol 2026; In press DOI: https://doi.org/10.5662/wjm.120387
PDF	120387-in-press.pdf

Received	2026-02-25 03:04
Peer-Review Started	2026-02-25 03:12
First Decision by Editorial Office Director	2026-04-03 02:40
Return for Revision	2026-04-03 02:40
Revised	2026-04-22 16:09
Publication Fee Transferred
Second Decision by Editor	2026-06-04 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 03:29
Articles in Press	2026-06-04 03:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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