Publication Name	World Journal of Clinical Oncology
Manuscript ID	120388
Country	Qatar

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Evolving patterns of gastrointestinal stromal tumor presentation, management, and outcome over three decades: A middle Eastern Retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Moamena Ahmed El-Matbouly, Hassan Al-Thani, Ayman El-Menyar, Maryam Al-Sulaiti, Mohammad Asim, Mohammad Al Yaseen, Ahmed Suliman, Ahmed Albahrani, Issam Al-Bozom and Abdelhakem Tabeb
Funding Agency and Grant Number
Corresponding Author	Ayman El-Menyar, Department of Surgery, Hamad Medical Corporation, Al-Rayyan Street, Doha 3050, Qatar. aymanco65@yahoo.com
Key Words	Gastrointestinal stromal tumor; Epidemiology; Minimally Invasive surgical procedures; Imatinib mesylate; Recurrence
Core Tip	Gastrointestinal stromal tumors (GIST) represent the most common mesenchymal neoplasms of the gastrointestinal tract, with evolving management driven by advances in molecular profiling, targeted therapy, and minimally invasive surgical techniques. However, longitudinal regional data describing real-world outcomes remain limited. This study aimed to evaluate trends in presentation, surgical management, risk stratification, and outcomes of GIST over three decades in a Middle Eastern country. Gastric primary tumors were the most common GIST. Over three decades, the management of GIST in this regional cohort has evolved toward increased adoption of minimally invasive surgery, molecularly guided therapy, and risk-adapted treatment strategies. High rates of complete resection and favorable disease-free survival highlight the effectiveness of multidisciplinary care. These findings provide region-specific benchmarks to inform clinical practices and future collaborations across multiple centers.
Citation	El-Matbouly MA, Al-Thani H, El-Menyar A, Al-Sulaiti M, Asim M, Al Yaseen M, Suliman A, Albahrani A, Al-Bozom I, Tabeb A. Evolving patterns of gastrointestinal stromal tumor presentation, management, and outcome over three decades: A Middle Eastern retrospective study. World J Clin Oncol 2026; In press

Received	2026-02-25 01:12
Peer-Review Started	2026-02-25 01:13
First Decision by Editorial Office Director	2026-03-02 08:46
Return for Revision	2026-03-02 08:46
Revised	2026-03-11 11:34
Publication Fee Transferred	2026-03-12 09:14
Second Decision by Editor	2026-05-22 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-22 07:42
Articles in Press	2026-05-22 07:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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