Publication Name	World Journal of Cardiology
Manuscript ID	120391
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Landiolol, electrical remodeling, and the emerging biology of ventricular arrhythmia control
Manuscript Source	Invited Manuscript
All Author List	Maryam Salimi, Ramesh Hariharan and Khashayar Hematpour
Funding Agency and Grant Number
Corresponding Author	Khashayar Hematpour, Department of Advanced Cardiopulmonary Therapies and Transplantations (ACTAT), University of Texas Health Sciences Center, McGovern Medical School, 6400 Fannin St, Houston, TX 77030, United States. khashayar.hematpour@gmail.com
Key Words	Sepsis; Landiolol; Ventricular arrhythmia; Electrical remodeling; Connexin-43; NaV1.5; β1-selective blockade; Conduction heterogeneity
Core Tip	Ventricular arrhythmias in sepsis may not be only a consequence of elevated heart rate, but rather the result of inflammation-driven electrical instability within the myocardium. Experimental data suggest that landiolol may influence this process by affecting key conduction proteins, including connexin-43 and NaV1.5. This perspective shifts the focus from simple rate control toward potential modulation of the arrhythmogenic substrate, highlighting the need for more targeted clinical investigation.
Citation	Salimi M, Hariharan R, Hematpour K. Landiolol, electrical remodeling, and the emerging biology of ventricular arrhythmia control. World J Cardiol 2026; In press

Received	2026-02-25 02:57
Peer-Review Started	2026-02-25 02:58
First Decision by Editorial Office Director	2026-03-09 08:54
Return for Revision	2026-03-09 08:54
Revised	2026-03-22 22:34
Publication Fee Transferred
Second Decision by Editor	2026-04-14 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-14 07:44
Articles in Press	2026-04-14 07:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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