| Category |
Pathology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Low accuracy and interobserver/intraobserver agreement for colorectal sessile serrated lesions: A multicenter diagnostic study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao Hu, Sheng-Bing Zhao, You-Dong Zhao, Xiang-Yu Sui, Song Zhang, Jia-Hui Wei, Xue-Fei Liu, Yu-Chuan Shi, Li Tang, Bing-Bing Zhang, Zhen Feng, Wei Cheng, Ming-Hua Zhu, Zhi Zhu, Zhao-Shen Li, Miao-Xia He, Yu Bai and Jing Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Noncommunicable Chronic Diseases-National Science and Technology Major Project |
No. 2023ZD0501601 |
| the China National Postdoctoral Program for Innovative Talents |
No. BX20230482 |
| the Shanghai Eastern Talent Youth Program |
No. QNWS2024100, No. QNWS2024108, No. BJKJ2025002 |
| the Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission |
No. 22CGA42 |
| the Natural Science Foundation of Shanghai |
No. 23ZR1478700 |
| the Shanghai Sailing Program |
No. 23YF1458600 |
| the Special Clinical Research on Health Industry of Shanghai Municipal Health Commission |
No. 20244Y0231 |
| the Shanghai Medical Innovation Research Project |
No. 23Y11902500 |
| the Shenkang Diagnosis and Treatment Technology Promotion and Optimization Management Project |
No. SHDC22025222, No. SHDC22026216 |
| the Naval Military Medical University General Incubation Fund |
No. 2023MS038 |
| the Naval Military Medical University Teaching Achievement Cultivation Project |
No. JPY2025B11 |
| the Naval Military Medical University Key Project on Teaching Reform |
No. JYG2024A08 |
| the Changhai Hospital Special Foundation for Clinical Research Program |
No. 2024LYB05 |
| the Changying Youth Seedling Plan |
|
|
| Corresponding Author |
Jing Zhang, MD, PhD, Department of Pathology, Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China. zhangjing@smmu.edu.cn |
| Key Words |
Colorectal polyps; Sessile serrated lesion; Pathological diagnosis; Diagnostic consistency; Histopathological assessment |
| Core Tip |
In this multicenter diagnostic study of 1176 colorectal lesions, pathologists’ accuracy and agreement for sessile serrated lesions (SSLs) and SSLs with dysplasia were evaluated. After clinical information was provided, the overall diagnostic accuracy improved from 66% to 72%; however, the diagnostic consistency of SSLs with dysplasia remained poor (κ = 0.114-0.132). Nuclear alterations (odds ratio = 10.45) and the cross-sectional crypt orientation (odds ratio = 5.27) were identified as factors that influenced diagnostic inconsistency. These results suggest that experience is insufficient to overcome the diagnostic challenges of SSLs. This finding reinforces the need for quantitative standards, algorithms for quality control of section orientation, and artificial intelligence-assisted curative devices to improve diagnostic precision. |
| Citation |
Hu H, Zhao SB, Zhao YD, Sui XY, Zhang S, Wei JH, Liu XF, Shi YC, Tang L, Zhang BB, Feng Z, Cheng W, Zhu MH, Zhu Z, Li ZS, He MX, Bai Y, Zhang J. Low accuracy and interobserver/intraobserver agreement for colorectal sessile serrated lesions: A multicenter diagnostic study. World J Gastroenterol 2026; In press |
