Publication Name	World Journal of Clinical Oncology
Manuscript ID	120414
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Immune microenvironment and immune cell dynamics in colitis-associated colorectal cancer: Mechanisms and therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Yu-Ying Wang, Hui Yang, Nan-Nan Wang and Lei Ding
Funding Agency and Grant Number	Funding Agency Grant Number the China Scholarship Council 202308110243 the National Natural Science Foundation of China 82471761
Corresponding Author	Lei Ding, Chief Physician, MD, PhD, Professor, Department of Gastrointestinal Oncology Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian, Haidian District, Beijing 100038, China. dinglei1005@126.com
Key Words	Colitis-associated colorectal cancer; Immune microenvironment; Immune cells; Cancer promotion; Cancer suppression
Core Tip	This manuscript focuses on the dual role - both anti-tumor and pro-tumor effects - played by immune cells within the microenvironment of colitis-associated colorectal cancer. Specifically, the article elucidates how inflammatory mediators, chemokines, and immune cells collectively drive the dynamic equilibrium between anti-tumor immunity and pro-tumor inflammation. By integrating the latest research advancements in the fields of immune cells, signaling molecules, and the gut microbiota, this review highlights the key immune signaling pathways and intercellular interactions that govern the progression of colitis-associated colorectal cancer.
Citation	Wang YY, Yang H, Wang NN, Ding L. Immune microenvironment and immune cell dynamics in colitis-associated colorectal cancer: Mechanisms and therapeutic implications. World J Clin Oncol 2026; In press

Received	2026-02-27 03:22
Peer-Review Started	2026-02-27 03:23
First Decision by Editorial Office Director	2026-03-06 09:17
Return for Revision	2026-03-06 09:17
Revised	2026-03-31 16:38
Publication Fee Transferred
Second Decision by Editor	2026-05-07 03:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 07:33
Articles in Press	2026-05-07 07:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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