Publication Name	World Journal of Experimental Medicine
Manuscript ID	120424
DOI	10.5493/wjem.120424
Country	Indonesia

Category	Research & Experimental Medicine
Manuscript Type	Observational Study
Article Title	Bacterial load and transforming growth factor-beta: Predicting the extent of lung damage in pulmonary tuberculosis patients
Manuscript Source	Invited Manuscript
All Author List	Putri Nila Kandi, M Harun Iskandar, Harry Akza Putrawan, Risna Halim Mubin, Syakib Bakri, Hasyim Kasim, Suriani Alimuddin, Resha Dermawansyah Rusman and Arifin Seweng
Funding Agency and Grant Number
Corresponding Author	Putri Nila Kandi, MD, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Jl. Perintis Kemerdekaan KM 11, Makassar 90245, Sulawesi Selatan, Indonesia. putrinilaakandi@gmail.com
Key Words	Pulmonary tuberculosis; Rapid molecular test; Bacterial load; Transforming growth factor-beta; Radiological lesion
Core Tip	Pulmonary tuberculosis (TB) severity is shaped by the interplay between bacterial burden and host immune responses. This study examined their association with radiological lesion extent in newly diagnosed patients. Bacterial load was significantly associated with moderate-extensive lung damage, whereas systemic transforming growth factor-β levels did not reflect disease severity, suggesting a more localized immune role in TB pathogenesis.
Citation	Kandi PN, Iskandar MH, Putrawan HA, Mubin RH, Bakri S, Kasim H, Alimuddin S, Rusman RD, Seweng A. Bacterial load and transforming growth factor-beta: Predicting the extent of lung damage in pulmonary tuberculosis patients. World J Exp Med 2026; In press DOI: https://doi.org/10.5493/wjem.120424
PDF	120424-in-press.pdf

Received	2026-02-27 03:21
Peer-Review Started	2026-02-27 03:21
First Decision by Editorial Office Director	2026-03-03 09:29
Return for Revision	2026-03-03 09:29
Revised	2026-03-06 05:45
Publication Fee Transferred
Second Decision by Editor	2026-06-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-11 08:28
Articles in Press	2026-06-11 08:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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