Publication Name	World Journal of Hepatology
Manuscript ID	120427
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Dong-Dong Yin, Wei-Yu Jiang, Yu-Ting Huang, Shu-Ping Zhou and Yin-Ci Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Health Research Program of Anhui No. AHWJ2023A30019 Clinical and Translational Research Project of Anhui Province No. 202527c10020090 and No. 202304295107020036 University-Industry Collaborative Education Program No. 230907010211931
Corresponding Author	Yin-Ci Zhang, The First Hospital, Anhui University of Science and Technology, No.203 Huaibin Road, Tianjia'an District, Huainan 232000, Anhui Province, China. 13345543605@163.com
Key Words	Methionine; Hepatocellular carcinoma; Epithelial-mesenchymal transition; Ferroptosis; ARNT2; UBE2Z
Core Tip	Aberrant methionine (Met) metabolism critically promotes the progression of hepatocellular carcinoma (HCC). Met deficiency may induce ferroptosis and inhibit epithelial-mesenchymal transition through the ARNT2/UBE2Z axis, thereby suppressing HCC progression, whereas Met supplementation reverses these effects. Furthermore, high expression levels of ARNT2 and UBE2Z predict unfavorable prognosis in HCC patients. Collectively, these findings indicate that the Met-ARNT2/UBE2Z pathway may serve as a novel anti-HCC therapeutic target.
Citation	Yin DD, Jiang WY, Huang YT, Zhou SP, Zhang YC. Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway. World J Hepatol 2026; In press

Received	2026-02-27 03:14
Peer-Review Started	2026-02-27 03:14
First Decision by Editorial Office Director	2026-03-20 11:18
Return for Revision	2026-03-21 03:10
Revised	2026-04-04 15:15
Publication Fee Transferred	2026-04-05 07:49
Second Decision by Editor	2026-05-11 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-11 09:15
Articles in Press	2026-05-11 09:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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