Publication Name	World Journal of Cardiology
Manuscript ID	120433
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Landiolol and septic ventricular arrhythmias: Revisiting the inflammation–fibrosis–Nav1.5/Cx43 electro-structural axis
Manuscript Source	Invited Manuscript
All Author List	Jiao Tang, Xue Deng, Ting Luo, Zhuoma Gesang, Zi-Ran Jia, Quzhun Danzeng and Tao Wang
Funding Agency and Grant Number	Funding Agency Grant Number Xizang Autonomous Region Science and Technology Program XZ202501YD0006 Medical Science Research Project of Sichuan Province S23014
Corresponding Author	Tao Wang, Chief Physician, MD, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20 South Renmin Road, Chengdu 610041, Sichuan Province, China. 44871875@qq.com
Key Words	Sepsis; Ventricular arrhythmia; Landiolol; β1 blocker; Cx43; Nav1.5; Conduction dispersion; Fibrosis; Electro structural remodeling; Precision critical care
Core Tip	Hu et al demonstrated that landiolol reduced ventricular arrhythmia burden in a septic rat model while attenuating inflammation, apoptosis, and fibrosis, improving conduction heterogeneity, and being accompanied by reciprocal changes in Cx43 and Nav1.5 expression. The key message is conceptual rather than definitive: Ultra-short-acting beta1 blockade may benefit selected septic patients by modulating an inflammation-fibrosis-Nav1.5/Cx43 electro-structural axis, not merely by slowing heart rate. Future studies should explicitly link expression to function through INa and gap-junction or hemichannel assays, define the safe dose and time window, and translate this framework through phenotype-guided clinical implementation.
Citation	Tang J, Deng X, Luo T, Gesang Z, Jia ZR, Danzeng Q, Wang T. Landiolol and septic ventricular arrhythmias: Revisiting the inflammation–fibrosis–Nav1.5/Cx43 electro-structural axis. World J Cardiol 2026; In press

Received	2026-02-27 03:26
Peer-Review Started	2026-02-27 03:26
First Decision by Editorial Office Director	2026-03-09 08:54
Return for Revision	2026-03-09 08:54
Revised	2026-03-22 20:56
Publication Fee Transferred
Second Decision by Editor	2026-04-21 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-21 07:18
Articles in Press	2026-04-21 07:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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