Publication Name	World Journal of Stem Cells
Manuscript ID	120457
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	ENaCδ aggravates gastroesophageal reflux disease via PI3K/AKT/mTOR: Human umbilical cord mesenchymal stem cells restore barrier function
Manuscript Source	Unsolicited Manuscript
All Author List	Cong Wang, Yi Li, Qian-Qian Chen and Jun Wan
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Natural Science Foundation 7232151
Corresponding Author	Jun Wan, MD, Department of Gastroenterology, The Second Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. wanjun_301@126.com
Key Words	Human umbilical cord mesenchymal stem cells; Gastroesophageal reflux disease; Humanized epithelial sodium channel δ mouse model; Epithelial sodium channel; Proton pump inhibitor
Core Tip	We developed a CRISPR/Cas9-generated humanized epithelial sodium channel δ mouse model to better mimic human gastroesophageal reflux disease. Humanized epithelial sodium channel δ aggravated acid-induced esophageal inflammation by activating the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, increasing interleukin 1 (IL-1), IL-1β, IL-17 and inducible nitric oxide synthase, and impairing barrier and contractile regulators (claudin-1 and myosin phosphatase target subunit 1). Human umbilical cord mesenchymal stem cells reversed these changes and outperformed proton pump inhibitor in suppressing IL-17 and restoring claudin-1/myosin phosphatase target subunit 1.
Citation	Wang C, Li Y, Chen QQ, Wan J. ENaCδ aggravates gastroesophageal reflux disease via PI3K/AKT/mTOR: Human umbilical cord mesenchymal stem cells restore barrier function. World J Stem Cells 2026; In press

Received	2026-03-03 10:39
Peer-Review Started	2026-03-03 10:39
First Decision by Editorial Office Director	2026-03-17 07:31
Return for Revision	2026-03-17 07:31
Revised	2026-03-31 12:06
Publication Fee Transferred
Second Decision by Editor	2026-04-27 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 07:28
Articles in Press	2026-05-07 07:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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