Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120469
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection
Manuscript Source	Unsolicited Manuscript
All Author List	Guanwu Wang, Carlos Otto, Dong Liu, Tarick M Al-Masri, Smiths S Lueong, Jens Siveke, Tom Luedde, Daniel Heise, Florian WR Vondran, Franziska Alexandra Meister, Georg Lurje, Ulf Neumann, Lara Heij and Jan Bednarsch
Funding Agency and Grant Number	Funding Agency Grant Number China Scholarship Council No. 202108430018 China Scholarship Council No. 202208080011
Corresponding Author	Jan Bednarsch, Department of Surgery and Transplantation, University Hospital Essen, Hufelandstrasse 55, Essen 45147, North Rhine-Westphalia, Germany. jan.bednarsch@uk-essen.de
Key Words	Cholangiocarcinoma; Single-nucleotide polymorphisms; ARID5B; LEPR; Prognostic biomarker
Core Tip	This study identifies germline ARID5B rs10740055 and LEPR rs1137101 polymorphisms as prognostic biomarkers in patients undergoing curative resection for intrahepatic and perihilar cholangiocarcinoma. In a cohort of 229 patients, the ARID5B rs10740055 AA genotype was consistently associated with significantly worse recurrence-free, cancer-specific, and overall survival, serving as an independent predictor particularly in intrahepatic cholangiocarcinoma. The LEPR rs1137101 GG genotype was additionally associated with shorter recurrence-free survival in intrahepatic tumors. These findings highlight the potential value of incorporating host genetic variants into postoperative risk stratification and personalized management strategies for cholangiocarcinoma.
Citation	Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FWR, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; In press

Received	2026-02-28 01:02
Peer-Review Started	2026-02-28 01:03
First Decision by Editorial Office Director	2026-03-06 08:36
Return for Revision	2026-03-06 08:36
Revised	2026-03-19 19:44
Publication Fee Transferred	2026-03-21 14:28
Second Decision by Editor	2026-04-28 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-28 09:00
Articles in Press	2026-04-28 09:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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