Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120472
DOI	10.4251/wjgo.120472
Country	Canada

Category	Oncology
Manuscript Type	Basic Study
Article Title	Dietary eicosapentaenoic and docosahexaenoic acids decrease prostanoids in the ileum of rats treated with irinotecan and 5-fluorouracil
Manuscript Source	Unsolicited Manuscript
All Author List	Sarah R Parsons, Irma M Rivas-Serna, M Thomas Clandinin and Vera C Mazurak
Funding Agency and Grant Number	Funding Agency Grant Number Canadian Institutes of Health Research No. PS165820
Corresponding Author	Vera C Mazurak, Professor, Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-002F Li Ka Shing Centre for Health Research, Edmonton T6G 2P5, Alberta, Canada. vmazurak@ualberta.ca
Key Words	Ileum; Oxylipins; Phospholipid fatty acids; Rat; Tumor; Chemotherapy; Colorectal cancer; N-3 fatty acids; Fish oil; Irinotecan
Core Tip	The present study is the first to investigate n-6- and n-3-derived oxylipin levels from ileum tissue after irinotecan + 5-fluorouracil and modification by dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The arachidonic acid (AA) metabolite 6-keto-prostaglandin F1α implicated in inhibiting water absorption and electrolyte dysregulation increased after irinotecan + 5-fluorouracil. Dietary EPA and DHA markedly reduced 6-keto-prostaglandin F1α and several other prostanoids while increasing protective and resolving mediators, lipoxin A4 (AA-derived) and protectin-D1 (DHA-derived). Oxylipin potential to reduce the risk of chemotherapy-induced adverse effects, such as diarrhea, should be explored in models of multi-cycle chemotherapy.
Citation	Parsons SR, Rivas-Serna IM, Clandinin MT, Mazurak VC. Dietary eicosapentaenoic and docosahexaenoic acids decrease prostanoids in the ileum of rats treated with irinotecan and 5-fluorouracil. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.120472
PDF	120472-in-press.pdf

Received	2026-02-27 01:30
Peer-Review Started	2026-02-27 01:30
First Decision by Editorial Office Director	2026-03-13 08:06
Return for Revision	2026-03-13 08:06
Revised	2026-03-25 17:21
Publication Fee Transferred	2026-06-24 21:06
Second Decision by Editor	2026-07-28 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:31
Articles in Press	2026-07-28 13:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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