| Category |
Medicine, General & Internal |
| Manuscript Type |
Minireviews |
| Article Title |
Body mass index and gastrointestinal inflammation: Bio-molecular pathophysiology
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Roberto Anaya-Prado, Andrea M Murrieta-Verduzco, Ivanna R Peña-Mascorro, Anna C Portillo-Valles, Alejandro Calderon-Velazquez, Hector Lopez-Hernandez, Dalia G Monge-Rosales, Jose L Montes de Oca-Martinez, Christopher E Castellanos-Garcia, Gustavo Servin-Romero, Roberto Anaya-Fernández, Ana P Cardenas-Fregoso, Michelle M Anaya-Fernández, Consuelo C Azcona-Ramirez and Cynthia N Heredia-Garcia |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Roberto Anaya-Prado, Director, FACS, MD, PhD, Professor, Research Dean, Senior Scientist, Department of Research, Department of Surgery, School of Medicine and Health Sciences, Tecnologico de Monterrey, Blvd Puerta de Hierro, No. 5150 Int 201B. Fraccionamiento Puerta de Hierro, Zapopan 45116, Jalisco, Mexico. robana1112@gmail.com |
| Key Words |
Body mass index; Obesity; Gastrointestinal inflammation; Pathophysiology |
| Core Tip |
Obesity has been recognized as a systemic metabolic condition and modulator of immune homeostasis. An impaired control of anti-inflammatory mediators has been associated with reduced levels of short-chain fatty acids. Some of these mediators involve interleukin (IL)-6, IL-1β and tumor necrosis factor-alpha, among others. These phenomena further perpetuate the inflammatory process all over the gastrointestinal (GI) tract. Current evidence demonstrates that higher BMI is linked to a chronic low-grade pro-inflammatory state (“metainflammation”) and several GI-relevant processes. In this article, we review the bimolecular inflammatory processes that have an impact on the GI tract and collateral organs such as the liver. |
| Citation |
Anaya-Prado R, Murrieta-Verduzco AM, Peña-Mascorro IR, Portillo-Valles AC, Calderon-Velazquez A, Lopez-Hernandez H, Monge-Rosales DG, Montes de Oca-Martinez JL, Castellanos-Garcia CE, Servin-Romero G, Anaya-Fernández R, Cardenas-Fregoso AP, Anaya-Fernández MM, Azcona-Ramirez CC, Heredia-Garcia CN. Body mass index and gastrointestinal inflammation: Bio-molecular pathophysiology. World J Gastrointest Pathophysiol 2026; In press |
