Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120485
Country	Japan

Category	Psychiatry
Manuscript Type	Opinion Review
Article Title	Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation
Manuscript Source	Unsolicited Manuscript
All Author List	Takahiko Nagamine
Funding Agency and Grant Number
Corresponding Author	Takahiko Nagamine, MD, PhD, Professor Emeritus, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp
Key Words	Kynurenine pathway; Dopamine; N-methyl-D-aspartate receptor; Neuroinflammation; Blood-brain barrier
Core Tip	The metabolic imbalance characterized by low kynurenic acid and high quinolinic acid in drug-naïve attention-deficit/hyperactivity disorder patients suggests a systemic failure of neuroprotective mechanisms. This biochemical environment likely disrupts N-methyl-D-aspartate receptor modulation, interfering with the maturation of dopaminergic pathways. The increased permeability of the blood-brain barrier in attention-deficit/hyperactivity disorder may allow these peripheral metabolites to exert a more direct influence on central neurotransmission, making the kynurenine pathway a primary therapeutic target.
Citation	Nagamine T. Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation. World J Clin Pediatr 2026; In press

Received	2026-02-27 09:03
Peer-Review Started	2026-02-27 09:03
First Decision by Editorial Office Director	2026-03-13 09:25
Return for Revision	2026-03-13 09:25
Revised	2026-03-13 10:33
Publication Fee Transferred
Second Decision by Editor	2026-05-07 03:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 06:58
Articles in Press	2026-05-07 06:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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