Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	120491
DOI	10.4240/wjgs.120491
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Oxycodone-dexmedetomidine vs fentanyl analgesia in septic patients after gastric perforation surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Lian-Chao Men, Li-Zeng Wang, Cong-Ying Ma, Ying Zhang and Yu Han
Funding Agency and Grant Number	Funding Agency Grant Number Bethune Public Welfare Foundation - Enze Pain Management Medical Research Project ezmr2024-039
Corresponding Author	Yu Han, Department of Critical Care Medicine, Hejian Branch of Cangzhou Central Hospital, No. 32 Jingkai South Street, Cangzhou 062450, Hebei Province, China. hangyudr@163.com
Key Words	Oxycodone; Dexmedetomidine; Fentanyl; Sepsis; Gastric perforation; Analgesia; Sedation
Core Tip	Sepsis following gastric perforation surgery is associated with high morbidity and prolonged intensive care unit (ICU) stay. Optimizing postoperative analgesia and sedation may influence inflammatory response and organ recovery in these patients. This retrospective cohort study demonstrates that oxycodone combined with dexmedetomidine provides superior analgesia and sedation compared with conventional fentanyl, with improved inflammatory control, enhanced hemodynamic stability, shorter ICU stay, reduced mechanical ventilation duration, and a lower incidence of delirium. These findings support the clinical value of dexmedetomidine-based multimodal analgesia strategies in septic patients after gastric perforation surgery.
Citation	Men LC, Wang LZ, Ma CY, Zhang Y, Han Y. Oxycodone-dexmedetomidine vs fentanyl analgesia in septic patients after gastric perforation surgery. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.120491
PDF	120491-in-press.pdf

Received	2026-02-27 09:59
Peer-Review Started	2026-02-27 09:59
First Decision by Editorial Office Director	2026-03-12 07:45
Return for Revision	2026-03-12 07:45
Revised	2026-03-31 07:36
Publication Fee Transferred
Second Decision by Editor	2026-07-15 02:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-15 06:09
Articles in Press	2026-07-15 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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