Publication Name	World Journal of Clinical Oncology
Manuscript ID	120495
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Enteric neural-tumor interactions in gastrointestinal malignancies and therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Si-Rui Wang, Ting-Lan Cao, Zeng-Ai Xia and Hui-Zhong Jiang
Funding Agency and Grant Number
Corresponding Author	Hui-Zhong Jiang, PhD, Professor, Researcher, Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Beijing 100700, China. jianghz93@126.com
Key Words	Enteric nervous system; Gastrointestinal cancer; Tumor microenvironment; Gut-brain axis; Cancer neuroscience
Core Tip	In this review, we propose that the enteric nervous system (ENS) is an active regulator of gastrointestinal malignancies rather than a passive bystander. We summarize how tumors remodel adjacent enteric neuroglial networks and how ENS-derived neurotransmitters and glial signals in turn shape tumor stemness, immune evasion, stromal remodeling, and perineural invasion. We further connect local tumor microenvironment dynamics with systemic brain-gut signaling and highlight druggable neural pathways as potential adjunctive targets for tumor control and symptom management.
Citation	Wang SR, Cao TL, Xia ZA, Jiang HZ. Enteric neural-tumor interactions in gastrointestinal malignancies and therapeutic implications. World J Clin Oncol 2026; In press

Received	2026-02-28 02:20
Peer-Review Started	2026-02-28 02:20
First Decision by Editorial Office Director	2026-04-15 09:09
Return for Revision	2026-04-15 09:09
Revised	2026-04-28 15:19
Publication Fee Transferred
Second Decision by Editor	2026-05-19 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-19 07:37
Articles in Press	2026-05-19 07:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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