Publication Name	World Journal of Gastroenterology
Manuscript ID	120498
DOI	10.3748/wjg.120498
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Rapid progression to liver failure following pancreatoduodenectomy in an adolescent: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Han Hu, Yu-Juan Liu, Mei-Chuan Li, Yan Li and Shi-De Lin
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Research Foundation of Zunyi City No. ZSKH-HZ [2023] 222 Guizhou Provincial Science and Technology Program No. QKHJC-ZK [2024] 315
Corresponding Author	Shi-De Lin, Chief Physician, MD, Professor, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi 563003, Guizhou Province, China. linshide6@zmu.edu.cn
Key Words	Adolescent; Pylorus-preserving pancreatoduodenectomy; Pancreatic exocrine insufficiency; Steatohepatitis; Cirrhosis; Acute-on-chronic liver failure; Case report
Core Tip	This report describes a 14-year-old male patient who developed cirrhosis and liver failure after pylorus-preserving pancreatoduodenectomy. Despite pancreatic enzyme replacement therapy, the patient experienced long-term refractory steatorrhea, severe malnutrition, and trace element deficiencies. Malnutrition-associated steatohepatitis and decompensated cirrhosis occurred 4 years postoperatively, followed by progression to liver failure and death from multi-organ dysfunction 2 years later. This case highlights that adolescent patients post-pylorus-preserving pancreatoduodenectomy, due to developmental growth demands, have specific and stringent requirements for pancreatic enzyme replacement and nutritional management. Inadequate management can lead to rapid, fatal progression to cirrhosis and liver failure.
Citation	Hu H, Liu YJ, Li MC, Li Y, Lin SD. Rapid progression to liver failure following pancreatoduodenectomy in an adolescent: A case report. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120498
PDF	120498-in-press.pdf

Received	2026-02-28 01:48
Peer-Review Started	2026-02-28 01:56
First Decision by Editorial Office Director	2026-04-04 03:06
Return for Revision	2026-04-04 03:06
Revised	2026-04-28 05:18
Publication Fee Transferred	2026-04-30 10:06
Second Decision by Editor	2026-06-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-08 07:53
Articles in Press	2026-06-08 07:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com