Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120525
Country	Viet Nam

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Longitudinal fibrosis-4 monitoring: A promising approach for hepatocellular carcinoma risk stratification in treatment-naïve chronic hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Hai Nguyen Ngoc Dang, Thang Viet Luong, Hung Minh Vu, Kim Yen Nguyen, Hung Tran Xuan and Bich Ngoc Hoang Thi
Funding Agency and Grant Number
Corresponding Author	Bich Ngoc Hoang Thi, MD, Researcher, Department of Outpatient, Gia An 115 Hospital, 05, 17A Street, Binh Tri Dong B Ward, Binh Tan District, Ho Chi Minh City 700000, Viet Nam. hoangngoc.yhue.a@gmail.com
Key Words	Chronic hepatitis C virus; Hepatocellular carcinoma; Fibrosis-4; Longitudinal monitoring; Risk stratification; Surveillance
Core Tip	Longitudinal fibrosis-4 (FIB-4) monitoring may improve hepatocellular carcinoma risk stratification in untreated chronic hepatitis C beyond a single baseline assessment. Rising FIB-4 trajectories may reflect ongoing fibrogenesis and progressive portal remodeling, but interpretation requires caution because of age-related drift, biological variability, and nonhepatic confounding. At present, longitudinal ΔFIB-4 should be viewed mainly as a tool for long-term risk enrichment. High-risk patterns may justify confirmatory elastography and closer surveillance, pending prospective validation.
Citation	Dang HNN, Viet Luong T, Minh Vu H, Nguyen KY, Tran Xuan H, Hoang Thi BN. Longitudinal fibrosis-4 monitoring: A promising approach for hepatocellular carcinoma risk stratification in treatment-naïve chronic hepatitis C. World J Gastrointest Oncol 2026; In press

Received	2026-03-02 03:27
Peer-Review Started	2026-03-02 03:28
First Decision by Editorial Office Director	2026-03-09 08:45
Return for Revision	2026-03-09 08:45
Revised	2026-03-20 17:40
Publication Fee Transferred
Second Decision by Editor	2026-05-18 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 07:17
Articles in Press	2026-05-18 07:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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