Publication Name	World Journal of Experimental Medicine
Manuscript ID	120531
DOI	10.5493/wjem.120531
Country	India

Category	Orthopedics
Manuscript Type	Review
Article Title	Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers predicting bone resorption-related disorders
Manuscript Source	Invited Manuscript
All Author List	Tapesh Lalotra, Arunagiri Gunasekar, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu, Viji Devanand and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Receptor activator of NF-kappaB; Receptor activator of NF-kappaB/receptor activator of NF-kappaB ligand; Osteoprotegerin axis; Osteoclast; Osteoporosis
Core Tip	The receptor activator of NF-kappaB/receptor activator of NF-kappaB ligand (RANKL)/osteoprotegerin (OPG) pathway is a pivotal bone remodelling pathway and its disruption is responsible for the osteoclast-driven bone resorption in the disease states of osteoporosis, arthritis and bone-related cancer. Plasma RANKL and OPG, and their ratio, may be more sensitive indicators for diagnosis, fracture prediction and therapy assessment. While assays are variable, there is evidence that the RANKL/OPG ratio could be a better predictor than either marker alone - and has the potential to improve diagnosis, treatment and outcomes in bone resorption disease.
Citation	Lalotra T, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Muthu S, Devanand V, Jeyaraman M. Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers predicting bone resorption-related disorders. World J Exp Med 2026; In press DOI: https://doi.org/10.5493/wjem.120531
PDF	120531-in-press.pdf

Received	2026-03-01 09:14
Peer-Review Started	2026-03-01 09:19
First Decision by Editorial Office Director	2026-03-27 10:47
Return for Revision	2026-03-27 10:47
Revised	2026-04-09 14:20
Publication Fee Transferred
Second Decision by Editor	2026-06-04 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 03:48
Articles in Press	2026-06-04 03:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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