Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	120555
DOI	10.4240/wjgs.120555
Country	Morocco

Category	Oncology
Manuscript Type	Opinion Review
Article Title	Evolving landscape of biomarkers in colorectal cancer: From interleukin-8 to integrated multi-marker strategies
Manuscript Source	Unsolicited Manuscript
All Author List	Nabil Ismaili
Funding Agency and Grant Number
Corresponding Author	Nabil Ismaili, Chairman, Chief Pharmacist, Professor, Department of Medical Oncology, Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Health (FM6SS), Mohammed Taïeb Naciri Street, Anfa City, Hay Hassan Municipality, Casablanca 82403, Casablanca-Settat, Morocco. nismaili@um6ss.ma
Key Words	Colorectal cancer; Interleukin-8; Biomarkers; Circulating tumor DNA; Carcinoembryonic antigen; Minimal residual disease; Liquid biopsy; Precision oncology; Methylation; Tumor microenvironment
Core Tip	Serum interleukin-8 (IL-8) levels are significantly elevated in patients with colorectal cancer and demonstrate moderate diagnostic accuracy (area under the curve, 0.68). Given this modest discriminatory performance and the absence of external validation, IL-8 does not currently meet the criteria for clinical implementation as a standalone diagnostic biomarker. Although IL-8 has shown independent associations in multivariate analyses, its clinical role remains investigational. Within the evolving biomarker landscape, where mismatch repair status, perioperative carcinoembryonic antigen, and postoperative circulating tumor DNA currently have stronger supportive evidence, IL-8 should be regarded as an investigational biomarker requiring prospective validation before clinical integration. No study to date has demonstrated that IL-8-guided strategies improve clinical outcomes in patients with colorectal cancer.
Citation	Ismaili N. Evolving landscape of biomarkers in colorectal cancer: From interleukin-8 to integrated multi-marker strategies. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.120555
PDF	120555-in-press.pdf

Received	2026-03-03 03:37
Peer-Review Started	2026-03-03 03:38
First Decision by Editorial Office Director	2026-03-09 08:37
Return for Revision	2026-03-09 08:37
Revised	2026-03-18 08:08
Publication Fee Transferred
Second Decision by Editor	2026-08-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:10
Articles in Press	2026-08-28 09:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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