Publication Name	World Journal of Gastroenterology
Manuscript ID	120563
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Clinical efficacy of pharmacological and non-pharmacological interventions for constipation-predominant irritable bowel syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Chen Li, Ji-Wu Yang, Si-Yuan Zhang, Wei Cheng, Hong-Bo Shi, Hai-Bin Shi and Chuan Li
Funding Agency and Grant Number	Funding Agency Grant Number Yunnan Provincial Department of Education Scientific Research Fund Project No. 2023Y0996
Corresponding Author	Ji-Wu Yang, Professor, Department of General Surgery II, The First Affiliated Hospital of Dali University, No. 32 Carlsberg Avenue, Dali Bai Autonomous Prefecture, Dali 671000, Yunnan Province, China. yangjiwu64@126.com
Key Words	Constipation-predominant irritable bowel syndrome; Pharmacological treatment; Non-pharmacological treatment; Clinical efficacy; Network meta-analysis; Systematic review
Core Tip	A comprehensive review and network meta-analysis has been conducted to determine the effectiveness of pharmacological and non-pharmacological therapies for constipation dominant irritable bowel syndrome. The assessment considered 14 different interventions depending on the important outcomes like frequency of bowel movements, consistency of stool, severity of symptoms, quality of life and adverse effects. According to the research, transcutaneous auricular vagus nerve stimulation, tenapanor, acupuncture, and probiotics are quite effective. These findings suggest the need for more personalized treatment approaches, and the need for further high-quality trials to confirm.
Citation	Li C, Yang JW, Zhang SY, Cheng W, Shi HB, Shi HB, Li C. Clinical efficacy of pharmacological and non-pharmacological interventions for constipation-predominant irritable bowel syndrome. World J Gastroenterol 2026; In press

Received	2026-03-03 03:07
Peer-Review Started	2026-03-03 03:07
First Decision by Editorial Office Director	2026-04-13 09:32
Return for Revision	2026-04-13 09:32
Revised	2026-05-02 07:37
Publication Fee Transferred	2026-05-09 15:38
Second Decision by Editor	2026-08-26 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-26 08:34
Articles in Press	2026-08-26 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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