Publication Name	World Journal of Gastroenterology
Manuscript ID	120568
DOI	10.3748/wjg.120568
Country	Ireland

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Anti-glutamic acid decarboxylase autoimmunity presenting as chronic intestinal pseudo-obstruction with dysautonomia and late-onset autoimmune diabetes: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Mohamed Kharief, Roz O’Byrne, Karl William, Mohammed Ali Hasabarsoul, Orla Tuohy and Ashraf Morcos
Funding Agency and Grant Number
Corresponding Author	Mohamed Kharief, MD, Department of Gastroenterology, University Hospital Waterford, Dunmore Road, Waterford X91 ER8E, Ireland. mohdkharief@gmail.com
Key Words	Chronic intestinal pseudo-obstruction; Anti-glutamic acid decarboxylase antibodies; Autoimmune dysmotility; Enteric neuropathy; Intravenous immunoglobulin; Rituximab; Case report
Core Tip	Chronic intestinal pseudo-obstruction is a rare and diagnostically challenging disorder that may be associated with autoimmune mechanisms. This case highlights anti-glutamic acid decarboxylase antibody-associated dysautonomia presenting with gastrointestinal dysmotility and evolving insulin-dependent diabetes mellitus. It underscores the importance of considering autoimmune etiologies in unexplained chronic intestinal pseudo-obstruction and demonstrates the potential benefit of immunomodulatory therapy, including corticosteroids, intravenous immunoglobulin, and rituximab, in achieving sustained clinical improvement.
Citation	Kharief M, O’Byrne R, William K, Hasabarsoul MA, Tuohy O, Morcos A. Anti-glutamic acid decarboxylase autoimmunity presenting as chronic intestinal pseudo-obstruction with dysautonomia and late-onset autoimmune diabetes: A case report. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120568
PDF	120568-in-press.pdf

Received	2026-03-02 03:06
Peer-Review Started	2026-03-02 05:46
First Decision by Editorial Office Director	2026-03-20 11:31
Return for Revision	2026-03-20 11:31
Revised	2026-04-18 15:54
Publication Fee Transferred	2026-04-23 22:40
Second Decision by Editor	2026-06-10 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-10 08:11
Articles in Press	2026-06-10 08:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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